The EU-ADR reference set A reference set of 43 drug-outcome pairs where we believe the drug causes the outcome ( positive controls) and 50 drug-outcome pairs where we believe the drug does not cause the outcome (negative controls). The controls involve 10 health outcomes of interest. Note that originally, there was an additional positive control (Nimesulide and acute liver injury), but Nimesulide is not in RxNorm, and is not available in many countries.
Source:R/MethodEvaluation.R
euadrReferenceSet.RdThe EU-ADR reference set A reference set of 43 drug-outcome pairs where we believe the drug causes the outcome ( positive controls) and 50 drug-outcome pairs where we believe the drug does not cause the outcome (negative controls). The controls involve 10 health outcomes of interest. Note that originally, there was an additional positive control (Nimesulide and acute liver injury), but Nimesulide is not in RxNorm, and is not available in many countries.
data(euadrReferenceSet)Format
A data frame with 399 rows and 10 variables:
- exposureId
Concept ID identifying the exposure
- exposureName
Name of the exposure
- outcomeId
Concept ID identifying the outcome
- outcomeName
Name of the outcome
- groundTruth
0 = negative control, 1 = positive control
- indicationId
Concept Id identifying the (primary) indication of the drug. To be used when one wants to nest the analysis within the indication
- indicationName
Name of the indication
- comparatorId
Concept ID identifying a comparator drug that can be used as a counterfactual
- comparatorName
Name of the comparator drug
- comparatorType
How the comparator was selected
References
Coloma PM, Avillach P, Salvo F, Schuemie MJ, Ferrajolo C, Pariente A, Fourrier-Reglat A, Molokhia M, Patadia V, van der Lei J, Sturkenboom M, Trifiro G. A reference standard for evaluation of methods for drug safety signal detection using electronic healthcare record databases. Drug Safety 36(1):13-23, 2013