The OMOP reference set A reference set of 165 drug-outcome pairs where we believe the drug causes the outcome ( positive controls) and 234 drug-outcome pairs where we believe the drug does not cause the outcome (negative controls). The controls involve 4 health outcomes of interest: acute liver injury, acute kidney injury, acute myocardial infarction, and GI bleeding.

data(omopReferenceSet)

## Format

A data frame with 399 rows and 10 variables:

exposureId

Concept ID identifying the exposure

exposureName

Name of the exposure

outcomeId

Concept ID identifying the outcome

outcomeName

Name of the outcome

groundTruth

0 = negative control, 1 = positive control

indicationId

Concept Id identifying the (primary) indication of the drug. To be used when one wants to nest the analysis within the indication

indicationName

Name of the indication

comparatorId

Concept ID identifying a comparator drug that can be used as a counterfactual

comparatorName

Name of the comparator drug

comparatorType

How the comparator was selected

## References

Ryan PB, Schuemie MJ, Welebob E, Duke J, Valentine S, Hartzema AG. Defining a reference set to support methodological research in drug safety. Drug Safety 36 Suppl 1:S33-47, 2013