Fit the null distribution using non-normal log-likelihood approximations

fitNullNonNormalLl fits the null distribution to a set of negative controls

fitNullNonNormalLl(likelihoodApproximations)

Arguments

likelihoodApproximations

Either a data frame containing normal, skew-normal, or custom parametric likelihood approximations, or a list of (adaptive) grid likelihood profiles.

Value

An object containing the parameters of the null distribution.

Details

This function fits a Gaussian function to the negative control estimates, using non-normal approximations of the per-negative control log likelihood.

Examples

data(sccs)
negatives <- sccs[sccs$groundTruth == 0, ]
null <- fitNullNonNormalLl(negatives)
#> Detected data following normal distribution
null
#> Estimated null distribution
#> 
#>      Estimate
#> Mean   0.7920
#> SD     0.2835