These conventions have been curated to show how to consider calculating cumulative and daily drug dose for a given exposure record. These are high-level examples meant to demonstrate how one might use the DRUG_STRENGTH table and they do not take into account switching or stockpiling.

**1. Tablets and other fixed amount
formulations**

**Example**: Acetaminophen
(Paracetamol) 500 mg, 20 tablets.

**DRUG_STRENGTH** The
denominator_unit is empty

**DRUG_EXPOSURE** The
quantity refers to number of pieces, e.g. tablets.

*In the
example*: 20

`Ingredient dose= quantity x amount_value [amount_unit_concept_id]`

Acetaminophen dose = 20 x 500mg = 10,000mg

Daily dose =
Acetaminophen dose/drug duration

**2. Puffs of an inhaler**

**Note**: There is no difference to use case 1 above
besides that the DRUG_STRENGTH table may put {actuat} in the denominator
unit. In this case the strength is provided in the numerator.

**DRUG_STRENGTH** The denominator_unit is {actuat}

**DRUG_EXPOSURE** The quantity refers to the number of
pieces, e.g. puffs

`Ingredient dose= quantity x numerator_value [numerator_unit_concept_id]`

Daily dose = Ingredient dose/drug duration

**3. Quantified
Drugs which are formulated as a concentration**

**Example**: The Clinical Drug is Acetaminophen 250 mg/mL
in a 5mL oral suspension. The Quantified Clinical Drug would have 1250
mg / 5 ml in the DRUG_STRENGTH table. Two suspensions are dispensed.

**DRUG_STRENGTH** The denominator_unit is either mg or mL.
The denominator_value might be different from 1.

**DRUG_EXPOSURE** The quantity refers to a fraction or
multiple of the pack.

*In the example*: 2

`Ingredient dose= quantity x numerator_value [numerator_unit_concept_id]`

*Acetaminophen dose* = 2 x 1250mg = 2500mg

Daily dose =
Acetaminophen dose/drug duration

**4. Drugs with the total
amount provided in quantity, e.g. chemotherapeutics**

**Example**: 42799258 “Benzyl Alcohol 0.1 ML/ML / Pramoxine
hydrochloride 0.01 MG/MG Topical Gel” dispensed in a 1.25oz pack.

**DRUG_STRENGTH** The denominator_unit is either mg or
mL.

**Example**: Benzyl Alcohol in mL and Pramoxine
hydrochloride in mg

**DRUG_EXPOSURE** The quantity
refers to mL or g.

**Example**: 1.25 x 30
*(conversion factor oz -> mL)* = 37

`Ingredient dose= quantity x numerator_value [numerator_unit_concept_id]`

*Benzyl Alcohol dose* = 37 x 0.1mL = 3.7mL

Daily dose =
Benzyl Alcohol dose/drug duration

*Pramoxine hydrochloride
dose* = 37 x 0.01mg x 1000 = 370mg

Daily dose = Pramoxine
hydrochloride dose/drug duration

**Note**: The
analytical side should check the denominator in the DRUG_STRENGTH table.
As mg is used for the second ingredient the factor 1000 will be applied
to convert between g and mg.

**5. Compounded
drugs**

**Example**: Ibuprofen 20%/Piroxicam
1% Cream, 30ml in 5ml tubes.

**DRUG_STRENGTH** We need
entries for the ingredients of Ibuprofen and Piroxicam, probably with an
amount_value of 1 and a unit of mg.

**DRUG_EXPOSURE**
The quantity refers to the total amount of the compound. Use one record
in the DRUG_EXPOSURE table for each compound.

**Example**: 20% Ibuprofen of 30ml = 6mL, 1% Piroxicam of
30ml = 0.3mL

`Ingredient dose= Depends on the drugs involved: One of the use cases above.`

*Ibuprofen dose* = 6 x 1mg x 1000 = 6000mg

Daily dose =
Ibuprofen dose/drug duration

*Piroxicam dose* = 0.3 x 1mg x
1000 = 300mg

Daily dose = Piroxicam dose/drug duration

**Note**: The analytical side determines that the
denominator for both ingredients in the DRUG_STRENGTH table is mg and
applies the factor 1000 to convert between mL/g and mg.

**6. Drugs with the active ingredient released over time,
e.g. patches**

**Example**: Ethinyl
Estradiol 0.000833 MG/HR / norelgestromin 0.00625 MG/HR Weekly
Transdermal Patch

**DRUG_STRENGTH** The denominator
units refer to hour.

**Example**: Ethinyl Estradiol
0.000833 mg/h / norelgestromin 0.00625 mg/h

**DRUG_EXPOSURE** The quantity refers to the number of
pieces.

**Example**: 1 patch

`Ingredient rate= numerator_value [numerator_unit_concept_id]`

*Ethinyl Estradiol rate* = 0.000833 mg/h

*norelgestromin
rate* 0.00625 mg/h

**Note**: This can be converted
to a daily dosage by multiplying it with 24. (Assuming 1 patch at a time
for at least 24 hours)