Health Analytics Data-to-Evidence Suite (HADES)

HADES (formally known as the OHDSI Methods Library) is a set of open source R packages for large scale analytics, including population characterization, population-level causal effect estimation, and patient-level prediction.

The packages offer R functions that together can be used to perform an observation study from data to estimates and supporting statistics, figures, and tables. The packages interact directly with observational data in the Common Data Model (CDM), and are designed to support both large datasets and large numbers of analyses (e.g. for testing many hypotheses including control hypotheses, and testing many analyses design variations). For this purpose, each Method package includes functions for specifying and subsequently executing multiple analyses efficiently. HADES supports best practices for use of observational data as learned from previous and ongoing research, such as transparency, reproducibility, as well as measuring of the operating characteristics of methods in a particular context and subsequent empirical calibration of estimates produced by the methods. For more information about HADES’ design considerations, please refer to the HADES paper.

HADES has already been used in many published clinical and methodological studies, as can be seen in the Publications section.


See the Support section for instructions on setting up the R environment for HADES, including Java and RTools. Each package in HADES can be installed independently, but it is also possible to install all HADES packages at once, as described here. You can learn how connect to your database using HADES here.

Learn How to Use HADES

Cover image Learn how to use HADES to produce reliable evidence from real-world data with The Book of OHDSI. Read it online.

Citing HADES

Please cite our HADES paper when using any of the HADES packages in your work:

Schuemie M, Reps J, Black A, Defalco F, Evans L, Fridgeirsson E, Gilbert JP, Knoll C, Lavallee M, Rao GA, Rijnbeek P, Sadowski K, Sena A, Swerdel J, Williams RD, Suchard M. Health-Analytics Data to Evidence Suite (HADES): Open-Source Software for Observational Research. Stud Health Technol Inform. 2024 Jan 25;310:966-970. doi: 10.3233/SHTI231108.


HADES is a set of R packages that execute against data in a database server. HADES supports traditional database systems (PostgreSQL, Microsoft SQL Server, and Oracle), parallel data warehouses (e.g. Amazon RedShift), as well as ‘Big Data’ platforms (e.g. Google BigQuery). HADES does not support MySQL. The full list of supported database platforms can be found here.


All packages in HADES are licensed under the Apache License 2.0, which allows users to use the software for any purpose, to distribute it, to modify it, and to distribute modified versions of the software under the terms of the license, without concern for royalties.