Packages

Below are the packages included in HADES. For each package a link is provided with more information, including instructions on how to install and use the package.

Population-level estimation

• CohortMethod

  New-user cohort studies using large-scale regression for propensity and outcome models.
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• SelfControlledCaseSeries

  Self-Controlled Case Series analysis using few or many predictors, includes splines for age and seasonality.
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• SelfControlledCohort

  A self-controlled cohort design, where time preceding exposure is used as control.
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• EvidenceSynthesis

  Routines for combining causal effect estimates and study diagnostics across multiple data sites in a distributed study.
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Patient-level prediction

• PatientLevelPrediction

  Build and evaluate predictive models for user-specified outcomes, using a wide array of machine learning algorithms.
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• DeepPatientLevelPrediction

  Performing patient level prediction using deep learning
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• EnsemblePatientLevelPrediction

  Building and validating ensemble patient-level predictive models.
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Characterization

• Characterization

  Various types of characterizations of a target and outcome cohort.
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• CohortIncidence

  Compute incidence rates and proportions
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Cohort construction and evaluation

• Capr

  Develop and manipulate complex cohort definitions in R
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• CirceR

  An R wrapper for Circe, a library for creating cohort definitions, expressing them as JSON, SQL, or Markdown.
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• CohortGenerator

  Instantiating cohorts in a database based on a set of cohort definitions.
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• PhenotypeLibrary

  The OHDSI Phenotype Library: a collection of community-maintained pre-definined cohorts.
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• CohortDiagnostics

  Generate a wide set of diagnostics to evaluate cohort definitions against databases in the CDM.
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• PheValuator

  Semi-automated evaluation of cohorts, producing metrics suchs as sensitivity, specificity, and positive and negative preditive value.
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• CohortExplorer

  Visually explore all individual-level data of patients in a cohort
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• Keeper

  Knowledge-Enhanced Electronic Profile Review
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Evidence Quality

• Achilles

  Generate descriptive statistics on an entire OMOP CDM database
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• DataQualityDashboard

  Expose and evaluate observational data quality.
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• EmpiricalCalibration

  Use negative control exposure-outcome pairs to profile and calibrate a particular analysis design.
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• MethodEvaluation

  Use real data and established reference sets as well as simulations injected in real data to evaluate the performance of methods.
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Supporting packages

• Andromeda

  Storing very large data objects on a local drive, while still making it possible to manipulate the data in an efficient manner.
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• BigKnn

  A large scale k-nearest neighbor classifier using the Lucene search engine.
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• BrokenAdaptiveRidge

  Broken Adaptive Ridge Regression with Cyclops.
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• Cyclops

  Highly efficient implementation of regularized logistic, Poisson and Cox regression.
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• DatabaseConnector

  Connect directly to a wide range of database platforms, including SQL Server, Oracle, and PostgreSQL.
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• Eunomia

  A standard CDM dataset for testing and demonstration purposes that runs on an embedded SQLite database.
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• FeatureExtraction

  Automatically extract large sets of features for user-specified cohorts using data in the CDM.
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• Hydra

  Hydrating package skeletons into executable R study packages based on specifications in JSON format.
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• IterativeHardThresholding

  Performing L0-based regressions using Cyclops
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• OhdsiSharing

  Securely sharing (large) files between OHDSI collaborators.
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• OhdsiShinyModules

  Contains shiny modules that can be used within shiny result interfaces
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• ParallelLogger

  Support for parallel computation with logging to console, disk, or e-mail.
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• ResultModelManager

  A lightweight utility for data migrations allowing old results to work with new shiny apps and data visualisations.
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• ROhdsiWebApi

  Interact with OHDSI WebAPI web services.
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• ShinyAppBuilder

  Interactively view analysis results across different types of analyses.
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• Strategus

  Coordinating and executing analytics using HADES packages
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• SqlRender

  Generate SQL on the fly for the various SQL dialects.
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