B Cohort definitions

This Appendix contains cohort definitions used throughout the book.

B.1 ACE Inhibitors

Initial Event Cohort

People having any of the following:

• a drug exposure of ACE inhibitors (Table B.1) for the first time in the person’s history

with continuous observation of at least 365 days prior and 0 days after event index date, and limit initial events to: all events per person.

Limit qualifying cohort to: all events per person.

End Date Strategy

Custom Drug Era Exit Criteria This strategy creates a drug era from the codes found in the specified concept set. If the index event is found within an era, the cohort end date will use the era’s end date. Otherwise, it will use the observation period end date that contains the index event.

Use the era end date of ACE inhibitors (Table B.1)

• allowing 30 days between exposures
• adding 0 days after exposure end

Cohort Collapse Strategy

Collapse cohort by era with a gap size of 30 days.

Concept Set Definitions

Table B.1: ACE inhibitors

Concept Id	Concept Name	Excluded	Descendants	Mapped
1308216	Lisinopril	NO	YES	NO
1310756	moexipril	NO	YES	NO
1331235	quinapril	NO	YES	NO
1334456	Ramipril	NO	YES	NO
1335471	benazepril	NO	YES	NO
1340128	Captopril	NO	YES	NO
1341927	Enalapril	NO	YES	NO
1342439	trandolapril	NO	YES	NO
1363749	Fosinopril	NO	YES	NO
1373225	Perindopril	NO	YES	NO

B.2 New Users of ACE Inhibitors Monotherapy

Initial Event Cohort

People having any of the following:

• a drug exposure of ACE inhibitors (Table B.2) for the first time in the person’s history

with continuous observation of at least 365 days prior and 0 days after event index date, and limit initial events to: earliest event per person.

Inclusion Rules

Inclusion Criteria #1: has hypertension diagnosis in 1 yr prior to treatment

Having all of the following criteria:

• at least 1 occurrences of a condition occurrence of Hypertensive disorder (Table B.3) where event starts between 365 days Before and 0 days After index start date

Inclusion Criteria #2: Has no prior antihypertensive drug exposures in medical history

Having all of the following criteria:

• exactly 0 occurrences of a drug exposure of Hypertension drugs (Table B.4) where event starts between all days Before and 1 days Before index start date

Inclusion Criteria #3: Is only taking ACE as monotherapy, with no concomitant combination treatments

Having all of the following criteria:

• exactly 1 distinct occurrences of a drug era of Hypertension drugs (Table B.4) where event starts between 0 days Before and 7 days After index start date

Limit qualifying cohort to: earliest event per person.

End Date Strategy

Custom Drug Era Exit Criteria. This strategy creates a drug era from the codes found in the specified concept set. If the index event is found within an era, the cohort end date will use the era’s end date. Otherwise, it will use the observation period end date that contains the index event.

Use the era end date of ACE inhibitors (Table B.2)

• allowing 30 days between exposures
• adding 0 days after exposure end

Cohort Collapse Strategy

Collapse cohort by era with a gap size of 0 days.

Concept Set Definitions

Table B.2: ACE inhibitors

Concept Id	Concept Name	Excluded	Descendants	Mapped
1308216	Lisinopril	NO	YES	NO
1310756	moexipril	NO	YES	NO
1331235	quinapril	NO	YES	NO
1334456	Ramipril	NO	YES	NO
1335471	benazepril	NO	YES	NO
1340128	Captopril	NO	YES	NO
1341927	Enalapril	NO	YES	NO
1342439	trandolapril	NO	YES	NO
1363749	Fosinopril	NO	YES	NO
1373225	Perindopril	NO	YES	NO

Table B.3: Hypertensive disorder

Concept Id	Concept Name	Excluded	Descendants	Mapped
316866	Hypertensive disorder	NO	YES	NO

Table B.4: Hypertension drugs

Concept Id	Concept Name	Excluded	Descendants	Mapped
904542	Triamterene	NO	YES	NO
907013	Metolazone	NO	YES	NO
932745	Bumetanide	NO	YES	NO
942350	torsemide	NO	YES	NO
956874	Furosemide	NO	YES	NO
970250	Spironolactone	NO	YES	NO
974166	Hydrochlorothiazide	NO	YES	NO
978555	Indapamide	NO	YES	NO
991382	Amiloride	NO	YES	NO
1305447	Methyldopa	NO	YES	NO
1307046	Metoprolol	NO	YES	NO
1307863	Verapamil	NO	YES	NO
1308216	Lisinopril	NO	YES	NO
1308842	valsartan	NO	YES	NO
1309068	Minoxidil	NO	YES	NO
1309799	eplerenone	NO	YES	NO
1310756	moexipril	NO	YES	NO
1313200	Nadolol	NO	YES	NO
1314002	Atenolol	NO	YES	NO
1314577	nebivolol	NO	YES	NO
1317640	telmisartan	NO	YES	NO
1317967	aliskiren	NO	YES	NO
1318137	Nicardipine	NO	YES	NO
1318853	Nifedipine	NO	YES	NO
1319880	Nisoldipine	NO	YES	NO
1319998	Acebutolol	NO	YES	NO
1322081	Betaxolol	NO	YES	NO
1326012	Isradipine	NO	YES	NO
1327978	Penbutolol	NO	YES	NO
1328165	Diltiazem	NO	YES	NO
1331235	quinapril	NO	YES	NO
1332418	Amlodipine	NO	YES	NO
1334456	Ramipril	NO	YES	NO
1335471	benazepril	NO	YES	NO
1338005	Bisoprolol	NO	YES	NO
1340128	Captopril	NO	YES	NO
1341238	Terazosin	NO	YES	NO
1341927	Enalapril	NO	YES	NO
1342439	trandolapril	NO	YES	NO
1344965	Guanfacine	NO	YES	NO
1345858	Pindolol	NO	YES	NO
1346686	eprosartan	NO	YES	NO
1346823	carvedilol	NO	YES	NO
1347384	irbesartan	NO	YES	NO
1350489	Prazosin	NO	YES	NO
1351557	candesartan	NO	YES	NO
1353766	Propranolol	NO	YES	NO
1353776	Felodipine	NO	YES	NO
1363053	Doxazosin	NO	YES	NO
1363749	Fosinopril	NO	YES	NO
1367500	Losartan	NO	YES	NO
1373225	Perindopril	NO	YES	NO
1373928	Hydralazine	NO	YES	NO
1386957	Labetalol	NO	YES	NO
1395058	Chlorthalidone	NO	YES	NO
1398937	Clonidine	NO	YES	NO
40226742	olmesartan	NO	YES	NO
40235485	azilsartan	NO	YES	NO

B.3 Acute Myocardial Infarction (AMI)

Initial Event Cohort

People having any of the following:

• a condition occurrence of Acute myocardial Infarction (Table B.5)

with continuous observation of at least 0 days prior and 0 days after event index date, and limit initial events to: all events per person.

For people matching the Primary Events, include: Having any of the following criteria:

• at least 1 occurrences of a visit occurrence of Inpatient or ER visit (Table B.6) where event starts between all days Before and 0 days After index start date and event ends between 0 days Before and all days After index start date

Limit cohort of initial events to: all events per person.

Limit qualifying cohort to: all events per person.

End Date Strategy

Date Offset Exit Criteria. This cohort definition end date will be the index event’s start date plus 7 days

Cohort Collapse Strategy

Collapse cohort by era with a gap size of 180 days.

Concept Set Definitions

Table B.5: Inpatient or ER visit

Concept Id	Concept Name	Excluded	Descendants	Mapped
314666	Old myocardial infarction	YES	YES	NO
4329847	Myocardial infarction	NO	YES	NO

Table B.6: Inpatient or ER visit

Concept Id	Concept Name	Excluded	Descendants	Mapped
262	Emergency Room and Inpatient Visit	NO	YES	NO
9201	Inpatient Visit	NO	YES	NO
9203	Emergency Room Visit	NO	YES	NO

B.4 Angioedema

Initial Event Cohort

People having any of the following:

• a condition occurrence of Angioedema (Table B.7)

with continuous observation of at least 0 days prior and 0 days after event index date, and limit initial events to: all events per person.

For people matching the Primary Events, include: Having any of the following criteria:

• at least 1 occurrences of a visit occurrence of Inpatient or ER visit (Table B.8) where event starts between all days Before and 0 days After index start date and event ends between 0 days Before and all days After index start date

Limit cohort of initial events to: all events per person.

Limit qualifying cohort to: all events per person.

End Date Strategy

This cohort definition end date will be the index event’s start date plus 7 days

Cohort Collapse Strategy

Collapse cohort by era with a gap size of 30 days.

Concept Set Definitions

Table B.7: Angioedema

Concept Id	Concept Name	Excluded	Descendants	Mapped
432791	Angioedema	NO	YES	NO

Table B.8: Inpatient or ER visit

Concept Id	Concept Name	Excluded	Descendants	Mapped
262	Emergency Room and Inpatient Visit	NO	YES	NO
9201	Inpatient Visit	NO	YES	NO
9203	Emergency Room Visit	NO	YES	NO

B.5 New Users of Thiazide-Like Diuretics Monotherapy

Initial Event Cohort

People having any of the following:

• a drug exposure of Thiazide or thiazide-like diuretic (Table B.9) for the first time in the person’s history

with continuous observation of at least 365 days prior and 0 days after event index date, and limit initial events to: earliest event per person.

Inclusion Rules

Inclusion Criteria #1: has hypertension diagnosis in 1 yr prior to treatment

Having all of the following criteria:

• at least 1 occurrences of a condition occurrence of Hypertensive disorder (Table B.10) where event starts between 365 days Before and 0 days After index start date

Inclusion Criteria #2: Has no prior antihypertensive drug exposures in medical history

Having all of the following criteria:

• exactly 0 occurrences of a drug exposure of Hypertension drugs (Table B.11) where event starts between all days Before and 1 days Before index start date

Inclusion Criteria #3: Is only taking ACE as monotherapy, with no concomitant combination treatments

Having all of the following criteria:

• exactly 1 distinct occurrences of a drug era of Hypertension drugs (Table B.11) where event starts between 0 days Before and 7 days After index start date

Limit qualifying cohort to: earliest event per person.

End Date Strategy

Custom Drug Era Exit Criteria. This strategy creates a drug era from the codes found in the specified concept set. If the index event is found within an era, the cohort end date will use the era’s end date. Otherwise, it will use the observation period end date that contains the index event.

Use the era end date of Thiazide or thiazide-like diuretic (Table B.9)

• allowing 30 days between exposures
• adding 0 days after exposure end

Cohort Collapse Strategy

Collapse cohort by era with a gap size of 0 days.

Concept Set Definitions

Table B.9: Thiazide or thiazide-like diuretic

Concept Id	Concept Name	Excluded	Descendants	Mapped
907013	Metolazone	NO	YES	NO
974166	Hydrochlorothiazide	NO	YES	NO
978555	Indapamide	NO	YES	NO
1395058	Chlorthalidone	NO	YES	NO

Table B.10: Hypertensive disorder

Concept Id	Concept Name	Excluded	Descendants	Mapped
316866	Hypertensive disorder	NO	YES	NO

Table B.11: Hypertension drugs

Concept Id	Concept Name	Excluded	Descendants	Mapped
904542	Triamterene	NO	YES	NO
907013	Metolazone	NO	YES	NO
932745	Bumetanide	NO	YES	NO
942350	torsemide	NO	YES	NO
956874	Furosemide	NO	YES	NO
970250	Spironolactone	NO	YES	NO
974166	Hydrochlorothiazide	NO	YES	NO
978555	Indapamide	NO	YES	NO
991382	Amiloride	NO	YES	NO
1305447	Methyldopa	NO	YES	NO
1307046	Metoprolol	NO	YES	NO
1307863	Verapamil	NO	YES	NO
1308216	Lisinopril	NO	YES	NO
1308842	valsartan	NO	YES	NO
1309068	Minoxidil	NO	YES	NO
1309799	eplerenone	NO	YES	NO
1310756	moexipril	NO	YES	NO
1313200	Nadolol	NO	YES	NO
1314002	Atenolol	NO	YES	NO
1314577	nebivolol	NO	YES	NO
1317640	telmisartan	NO	YES	NO
1317967	aliskiren	NO	YES	NO
1318137	Nicardipine	NO	YES	NO
1318853	Nifedipine	NO	YES	NO
1319880	Nisoldipine	NO	YES	NO
1319998	Acebutolol	NO	YES	NO
1322081	Betaxolol	NO	YES	NO
1326012	Isradipine	NO	YES	NO
1327978	Penbutolol	NO	YES	NO
1328165	Diltiazem	NO	YES	NO
1331235	quinapril	NO	YES	NO
1332418	Amlodipine	NO	YES	NO
1334456	Ramipril	NO	YES	NO
1335471	benazepril	NO	YES	NO
1338005	Bisoprolol	NO	YES	NO
1340128	Captopril	NO	YES	NO
1341238	Terazosin	NO	YES	NO
1341927	Enalapril	NO	YES	NO
1342439	trandolapril	NO	YES	NO
1344965	Guanfacine	NO	YES	NO
1345858	Pindolol	NO	YES	NO
1346686	eprosartan	NO	YES	NO
1346823	carvedilol	NO	YES	NO
1347384	irbesartan	NO	YES	NO
1350489	Prazosin	NO	YES	NO
1351557	candesartan	NO	YES	NO
1353766	Propranolol	NO	YES	NO
1353776	Felodipine	NO	YES	NO
1363053	Doxazosin	NO	YES	NO
1363749	Fosinopril	NO	YES	NO
1367500	Losartan	NO	YES	NO
1373225	Perindopril	NO	YES	NO
1373928	Hydralazine	NO	YES	NO
1386957	Labetalol	NO	YES	NO
1395058	Chlorthalidone	NO	YES	NO
1398937	Clonidine	NO	YES	NO
40226742	olmesartan	NO	YES	NO
40235485	azilsartan	NO	YES	NO

B.6 Patients Initiating First-Line Therapy for Hypertension

Initial Event Cohort

People having any of the following:

• a drug exposure of First-line hypertension drugs (Table B.12) for the first time in the person’s history

with continuous observation of at least 365 days prior and 365 days after event index date, and limit initial events to: earliest event per person.

Inclusion Rules

Having all of the following criteria:

• exactly 0 occurrences of a drug exposure of Hypertension drugs (Table B.13) where event starts between all days Before and 1 days Before index start date
• and at least 1 occurrences of a condition occurrence of Hypertensive disorder (Table B.14) where event starts between 365 days Before and 0 days After index start date

Limit cohort of initial events to: earliest event per person. Limit qualifying cohort to: earliest event per person.

End Date Strategy

No end date strategy selected. By default, the cohort end date will be the end of the observation period that contains the index event.

Cohort Collapse Strategy

Collapse cohort by era with a gap size of 0 days.

Concept Set Definitions

Table B.12: First-line hypertension drugs

Concept Id	Concept Name	Excluded	Descendants	Mapped
907013	Metolazone	NO	YES	NO
974166	Hydrochlorothiazide	NO	YES	NO
978555	Indapamide	NO	YES	NO
1307863	Verapamil	NO	YES	NO
1308216	Lisinopril	NO	YES	NO
1308842	valsartan	NO	YES	NO
1310756	moexipril	NO	YES	NO
1317640	telmisartan	NO	YES	NO
1318137	Nicardipine	NO	YES	NO
1318853	Nifedipine	NO	YES	NO
1319880	Nisoldipine	NO	YES	NO
1326012	Isradipine	NO	YES	NO
1328165	Diltiazem	NO	YES	NO
1331235	quinapril	NO	YES	NO
1332418	Amlodipine	NO	YES	NO
1334456	Ramipril	NO	YES	NO
1335471	benazepril	NO	YES	NO
1340128	Captopril	NO	YES	NO
1341927	Enalapril	NO	YES	NO
1342439	trandolapril	NO	YES	NO
1346686	eprosartan	NO	YES	NO
1347384	irbesartan	NO	YES	NO
1351557	candesartan	NO	YES	NO
1353776	Felodipine	NO	YES	NO
1363749	Fosinopril	NO	YES	NO
1367500	Losartan	NO	YES	NO
1373225	Perindopril	NO	YES	NO
1395058	Chlorthalidone	NO	YES	NO
40226742	olmesartan	NO	YES	NO
40235485	azilsartan	NO	YES	NO

Table B.13: Hypertension drugs

Concept Id	Concept Name	Excluded	Descendants	Mapped
904542	Triamterene	NO	YES	NO
907013	Metolazone	NO	YES	NO
932745	Bumetanide	NO	YES	NO
942350	torsemide	NO	YES	NO
956874	Furosemide	NO	YES	NO
970250	Spironolactone	NO	YES	NO
974166	Hydrochlorothiazide	NO	YES	NO
978555	Indapamide	NO	YES	NO
991382	Amiloride	NO	YES	NO
1305447	Methyldopa	NO	YES	NO
1307046	Metoprolol	NO	YES	NO
1307863	Verapamil	NO	YES	NO
1308216	Lisinopril	NO	YES	NO
1308842	valsartan	NO	YES	NO
1309068	Minoxidil	NO	YES	NO
1309799	eplerenone	NO	YES	NO
1310756	moexipril	NO	YES	NO
1313200	Nadolol	NO	YES	NO
1314002	Atenolol	NO	YES	NO
1314577	nebivolol	NO	YES	NO
1317640	telmisartan	NO	YES	NO
1317967	aliskiren	NO	YES	NO
1318137	Nicardipine	NO	YES	NO
1318853	Nifedipine	NO	YES	NO
1319880	Nisoldipine	NO	YES	NO
1319998	Acebutolol	NO	YES	NO
1322081	Betaxolol	NO	YES	NO
1326012	Isradipine	NO	YES	NO
1327978	Penbutolol	NO	YES	NO
1328165	Diltiazem	NO	YES	NO
1331235	quinapril	NO	YES	NO
1332418	Amlodipine	NO	YES	NO
1334456	Ramipril	NO	YES	NO
1335471	benazepril	NO	YES	NO
1338005	Bisoprolol	NO	YES	NO
1340128	Captopril	NO	YES	NO
1341238	Terazosin	NO	YES	NO
1341927	Enalapril	NO	YES	NO
1342439	trandolapril	NO	YES	NO
1344965	Guanfacine	NO	YES	NO
1345858	Pindolol	NO	YES	NO
1346686	eprosartan	NO	YES	NO
1346823	carvedilol	NO	YES	NO
1347384	irbesartan	NO	YES	NO
1350489	Prazosin	NO	YES	NO
1351557	candesartan	NO	YES	NO
1353766	Propranolol	NO	YES	NO
1353776	Felodipine	NO	YES	NO
1363053	Doxazosin	NO	YES	NO
1363749	Fosinopril	NO	YES	NO
1367500	Losartan	NO	YES	NO
1373225	Perindopril	NO	YES	NO
1373928	Hydralazine	NO	YES	NO
1386957	Labetalol	NO	YES	NO
1395058	Chlorthalidone	NO	YES	NO
1398937	Clonidine	NO	YES	NO
40226742	olmesartan	NO	YES	NO
40235485	azilsartan	NO	YES	NO

Table B.14: Hypertensive disorder

Concept Id	Concept Name	Excluded	Descendants	Mapped
316866	Hypertensive disorder	NO	YES	NO

B.7 Patients Initiating First-Line Therapy for Hypertension With >3 Yr Follow-Up

Same as cohort definition B.6 but with continuous observation of at least 365 days prior and 1095 days after event index date

B.8 ACE Inhibitor Use

Initial Event Cohort

People having any of the following:

• a drug exposure of ACE inhibitors (Table B.15)

with continuous observation of at least 0 days prior and 0 days after event index date, and limit initial events to: all events per person.

Limit qualifying cohort to: all events per person.

End Date Strategy

This strategy creates a drug era from the codes found in the specified concept set. If the index event is found within an era, the cohort end date will use the era’s end date. Otherwise, it will use the observation period end date that contains the index event.

Use the era end date of ACE inhibitors (Table B.15)

• allowing 30 days between exposures
• adding 0 days after exposure end

Cohort Collapse Strategy

Collapse cohort by era with a gap size of 30 days.

Concept Set Definitions

Table B.15: ACE inhibitors

Concept Id	Concept Name	Excluded	Descendants	Mapped
1308216	Lisinopril	NO	YES	NO
1310756	moexipril	NO	YES	NO
1331235	quinapril	NO	YES	NO
1334456	Ramipril	NO	YES	NO
1335471	benazepril	NO	YES	NO
1340128	Captopril	NO	YES	NO
1341927	Enalapril	NO	YES	NO
1342439	trandolapril	NO	YES	NO
1363749	Fosinopril	NO	YES	NO
1373225	Perindopril	NO	YES	NO

B.9 Angiotensin Receptor Blocker (ARB) Use

Same as cohort definition B.8 with Angiotensin Receptor Blockers (ARBs) (Table B.16) in place of ACE inhibitors (Table B.15).

Concept Set Definitions

Table B.16: Angiotensin Receptor Blockers (ARBs)

Concept Id	Concept Name	Excluded	Descendants	Mapped
1308842	valsartan	NO	YES	NO
1317640	telmisartan	NO	YES	NO
1346686	eprosartan	NO	YES	NO
1347384	irbesartan	NO	YES	NO
1351557	candesartan	NO	YES	NO
1367500	Losartan	NO	YES	NO
40226742	olmesartan	NO	YES	NO
40235485	azilsartan	NO	YES	NO

B.10 Thiazide Or Thiazide-Like Diuretic Use

Same as cohort definition B.8 with Thiazide or thiazide-like diuretic (Table B.17) in place of ACE inhibitors (Table B.15).

Concept Set Definitions

Table B.17: Thiazide or thiazide-like diuretic

Concept Id	Concept Name	Excluded	Descendants	Mapped
907013	Metolazone	NO	YES	NO
974166	Hydrochlorothiazide	NO	YES	NO
978555	Indapamide	NO	YES	NO
1395058	Chlorthalidone	NO	YES	NO

B.11 Dihydropyridine Calcium Channel Blocker (dCCB) Use

Same as cohort definition B.8 with dihydropyridine Calcium Channel Blocker (dCCB) (Table B.18) in place of ACE inhibitors (Table B.15).

Concept Set Definitions

Table B.18: Dihydropyridine Calcium channel blockers (dCCB)

Concept Id	Concept Name	Excluded	Descendants	Mapped
1318137	Nicardipine	NO	YES	NO
1318853	Nifedipine	NO	YES	NO
1319880	Nisoldipine	NO	YES	NO
1326012	Isradipine	NO	YES	NO
1332418	Amlodipine	NO	YES	NO
1353776	Felodipine	NO	YES	NO

B.12 Non-Dihydropyridine Calcium Channel Blocker (ndCCB) Use

Same as cohort definition B.8 with non-dihydropyridine Calcium channel blockers (ndCCB) (Table B.19) in place of ACE inhibitors (Table B.15).

Concept Set Definitions

Table B.19: non-dihydropyridine Calcium channel blockers (ndCCB)

Concept Id	Concept Name	Excluded	Descendants	Mapped
1307863	Verapamil	NO	YES	NO
1328165	Diltiazem	NO	YES	NO

B.13 Beta-Blocker Use

Same as cohort definition B.8 with Beta blockers (Table B.20) in place of ACE inhibitors (Table B.15).

Concept Set Definitions

Table B.20: Beta blockers

Concept Id	Concept Name	Excluded	Descendants	Mapped
1307046	Metoprolol	NO	YES	NO
1313200	Nadolol	NO	YES	NO
1314002	Atenolol	NO	YES	NO
1314577	nebivolol	NO	YES	NO
1319998	Acebutolol	NO	YES	NO
1322081	Betaxolol	NO	YES	NO
1327978	Penbutolol	NO	YES	NO
1338005	Bisoprolol	NO	YES	NO
1345858	Pindolol	NO	YES	NO
1346823	carvedilol	NO	YES	NO
1353766	Propranolol	NO	YES	NO
1386957	Labetalol	NO	YES	NO

B.14 Diuretic-Loop Use

Same as cohort definition B.8 with Diuretics - Loop (Table B.21) in place of ACE inhibitors (Table B.15).

Concept Set Definitions

Table B.21: Diuretics - Loop

Concept Id	Concept Name	Excluded	Descendants	Mapped
932745	Bumetanide	NO	YES	NO
942350	torsemide	NO	YES	NO
956874	Furosemide	NO	YES	NO

B.15 Diuretic-Potassium Sparing Use

Same as cohort definition B.8 with Diuretics - potassium sparing (Table B.22) in place of ACE inhibitors (Table B.15).

Concept Set Definitions

Table B.22: Diuretics - potassium sparing

Concept Id	Concept Name	Excluded	Descendants	Mapped
904542	Triamterene	NO	YES	NO
991382	Amiloride	NO	YES	NO

B.16 Alpha-1 Blocker Use

Same as cohort definition B.8 with Alpha-1 blocker (Table B.23) in place of ACE inhibitors (Table B.15).

Concept Set Definitions

Table B.23: Alpha-1 blocker

Concept Id	Concept Name	Excluded	Descendants	Mapped
1341238	Terazosin	NO	YES	NO
1350489	Prazosin	NO	YES	NO
1363053	Doxazosin	NO	YES	NO